Genomics and therapeutics
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics: translating functional genomics into rational therapeutics.
Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis f...
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RNA interference (RNAi) has the potential to address gene regulatory role in an efficient manner. Short interfering RNA (siRNA), the small RNA deriving from RNAi can control the gene regulation, by a technique called gene silencing. Gene silencing is "switching off" genes which are over expressed, in a sequence specific manner. SiRNA has been experimentally studied in disease therapy ...
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Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, ...
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Kidney cancer is not a single disease; it is made up of a number of different types of cancer, including clear cell, type 1 papillary, type 2 papillary, chromophobe, TFE3, TFEB, and oncocytoma. Sporadic, nonfamilial kidney cancer includes clear cell kidney cancer (75%), type 1 papillary kidney cancer (10%), papillary type 2 kidney cancer (including collecting duct and medullary RCC) (5%), the m...
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ژورنال
عنوان ژورنال: Pathology
سال: 2020
ISSN: 0031-3025
DOI: 10.1016/j.pathol.2020.01.127